The biologically active turmeric isolate curcumin (1) is under development as an

Question

The biologically active turmeric isolate curcumin (1) is under development as an anti-cancer chemotherapeutic agent. Recent mechanism-of-action studies have identified one potential target, the nuclear exporter protein CRM1. Curcumin inhibits nuclear trafficking by this protein, an activity that is speculated to underlie the promising anticancer and anti-inflammatory activity of 1. In fact, these studies suggest that curcumin forms a covalent linkage to one particular amino acid sidechain of CRM1 as the basis for its inhibitory activity. Which amino acid is likely involved? Select one: a b c d

Explanation / Answer

Hydrophobic environment for curcumin in the self-assembled gel include the hydrocarbon side chains of lysines or prolines exposed on the fibril surface. However the CRM1 protein complex has different side chains. They are

1. Hydrophobic side chains from helices: H11A H11B H12A

2. Acidic side chains: Glu 2, Glu 3

3. Basic side chains: Lys 560, Lys 522

we can not narrow them down to one or two simple amino acids. its a combination of many complex amino acids.

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