Biomaterial surface modification Describe two methods for biomaterial surface mo
ID: 1054912 • Letter: B
Question
Biomaterial surface modification
Describe two methods for biomaterial surface modification other than grafted polymer layers. Include a brief description of how the technique is performed, examples of the chemistries that can be imparted to the surface and one example of a healthcare application for each process. Given the structures of the three silane chemistries below, rank them in order from most hydrophobic to most hydrophilic. 2-[methoxy(polyethyleneoxy)9-12propyl]trimethoxysilane Heptadecafluoro-1, 1, 2, 2-tetrahydrodecyl)trimethoxysilane Octadecyl functional silaneExplanation / Answer
Surface modification can be done through various methods, which can be classified through three main groups: physical (physical adsorption, Langmuir blodgett film), chemical (oxidation by strong acids, ozone treatment, chemisorption, and flame treatment) and radiation (glow discharge, corona discharge, photo activation (UV), laser, ion beam, plasma immersion ion implantation, electron beam lithography, and -irradiation)
a) Surface modification of biomaterials with Plasma. Plasma modification is one way to alter the surface of biomaterials to enhance their properties.During plasma modification techniques, the surface is subjected to high levels of excited gases that alter the surface of the material. Plasma's are generally generated with a radio frequency (RF) field. The plasma is then used to expose the biomaterial surface, which can break or form chemical bonds. This is the result of physical collisions or chemical reactions of the excited gas molecules with the surface. This changes the surface chemistry and therefore surface energy of the material which affects the adhesion, biocompatibility, chemical inertness, lubricity, and sterilization of the material. useful in the area of dental, biosensors.
b) Surface modification of biomaterials with proteins: Protein surface modification of various types biomaterials (ceramics, polymers, metals, composites) is performed to ultimately increase biocompatibility of the material and interact as a bioactive material for specific applications. In various biomedical applications of developing implantable medical devices (such as pacemakers and stents), surface properties/interactions of proteins with a specific material must be evaluated with regards to biocompatibility as it plays a major role in determining a biological response. For instance, surface hydrophobicity or hydrophilicity of a material can be altered. Engineering biocompatability between the physiological environment and the surface material allows new medical products, materials and surgical procedures with additional biofunctionality. useful in the area of treatment for bone tissue or Cardiovascular tissue.
Q b) CF groups are most hydrophobic groups and OH grp is most hydrophilic group so
the order of hydrophobicity option 2 > option 1 > option 3.
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