1. Glucagon inhibits glycolysis in the liver because: a.) it increases the activ

Question

1. Glucagon inhibits glycolysis in the liver because:
a.) it increases the activity of Fructose-bisphosphatase 2
b.) it causes a decrease in Fructose-2,6-bisphosphate concentration 
c.) it decreases the activity of Phosphofructokinase-2
d.) it causes a decrease in Fructose-2,6-bisphosphate concentration 
e.) all of the above

2. Glucagon:
a.) is a hormone that is structurally similar to tyrosine
b.) is produced by the pituitary gland
c.) works with epinephrine to increase the supply of glucose to muscle cells
d.) is detected by a signal transduction pathway that utilizes IP3
e.) both b and c

Explanation / Answer

1. Glucagon inhibits glycolysis in the liver because:
a.) it increases the activity of Fructose-bisphosphatase 2            [Incorrect]

Glucagon inhibits F-bisPase 2. But glucagon activates F-2,6-bisPase.
b.) it causes a decrease in Fructose-2,6-bisphosphate concentration.         Incorrect

It Increase [F-2,6-bisP]
c.) it decreases the activity of Phosphofructokinase-2. Correct
d.) it causes a decrease in Fructose-2,6-bisphosphate concentration. incorrect
e.) all of the above

2. Glucagon:
a.) is a hormone that is structurally similar to tyrosine. Incorrect.

Glucagon is a oligopeptide with 29 residues. Epinephrine is derived from Tyrosine.
b.) is produced by the pituitary gland . Incorrect

Synthesized by pancreas
c.) works with epinephrine to increase the supply of glucose to muscle cells. Incorrect

Glucagon primarily raises glucose level in liver. Epinephrine work through different pathway to increase glucose supply to muscles cells.
d.) is detected by a signal transduction pathway that utilizes IP3. Correct

IP3 pathway is used by insulin to increase glucose level is tissues. Glucagon counteracts this pathways .
e.) both b and c

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