the Draw the reaction that shows l the 11. How does the low pH of the stomach af
ID: 1035174 • Letter: T
Question
the Draw the reaction that shows l the 11. How does the low pH of the stomach affect pro d pepude bo H of the stomach affect protei lde bond rure in such a way that the proteins are prepared foi is digestion of ( 12. tike the serine proteases (see Section 6-4), as a ymogen and is inactive at its site of synthesis, wher eis 7. Pepsin becomes activated when secreted inohpH pepsin is made peptide dis- residues are found in the active site of pepsin? Why does the basic asc formation of the active form of the enzyme. What amino acids the stomach sociates from the active site at pH 2 and is cleaved, resulting in the where it encounters a pH of 2. Pepsinogen contai peptide" that blocks its active site at pH 7. The basicExplanation / Answer
Ans. An aspartic acid residue at the active site of pepsin.
At pH 7 to 8 active site (asp) will be blocked by basic peptides and reduces its activity. -COOH moiety of active site of pepsin will convert into COO- and this inactive site is ready to bind to with basic peptide moiety.
At lower pH (maximal activity at pH 2) is due to the breakdown of pepsin enzyme and can easily bind with desire substrate.
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