? Prolines are most often found in the left-handed f repion of the Ramachandran

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? Prolines are most often found in the left-handed f repion of the Ramachandran plot 7, (2 pts) True or Fale Most heets have Type VI' tums commecing the strand reglons. Quaternary structure, folding/misfolding (17 pts 8. (5 pts) Describe what is special about the structure of collagen 9. (2 pts) The myosin protein found in muscle is: a. b. c. a globular protein a fibrous protein both a fibrous and globular protein 10. (2 pts) Which group of amino acids would be MOST likely to be found in the core of protein that is folded into a three-dimensional structure and soluble in water? (circle one) a. b. c. d. e. N, Y, and K I, L, and V V, T, and R M, S, and Y E, Y, and W 11. (2 pts) True or False ? All proteins are unable to fold unless assisted by chaperones 12. (2 pts) True or False ? The size of protein domains is limited by their ability to fold in a timely manner 13. (2 pts) True or False? In general, B-sheet proteins fold faster than a-helix proteins 14. (2 pts) Which disease is NoT one characterized by or associated with an unfolded protein (circle one) a. Alzheimer disease b. Creutzfeldt-Jakob disease (CJD) c. Parkinson disease d. Scurvy All of these diseases are linked to unfolded protein aggregates Myoglobin/Hemoglobin (19 pts) 15.(3 pts) What are the main functions of myoglobin and hemoglobin in the human body? 16. (2 pts) When oxygen binds to a heme-containing protein, the two open coordination bonds of Fe? are occupied by (circle one) a. b. c. d. e. one O atom and one amino acid atom one O2 molecule and one amino acid atom one 02 molecule and one heme atom two O atoms two 02 molecules

Explanation / Answer

8-Collagen is an abundant structural protein in all animals. In humans,it comprises one-third of the total protein, accounts for three-quarters of the dry weight of skin, is the regular arrangement of amino acids in each of the three chains of these collagen subunitsand is the most prevalent component of the extracellular matrix.

15-Myglobin is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates in general and in almost all mammals. It is related to hemoglobin, which is the iron- and oxygen-binding protein in blood, specifically in the red blood cells.

hemoglobin in the blood carries oxygen from the lungs or gills to the rest of the body.Hemoglobin also helps in the transportation of carbon dioxide and hydrogen ions back to the lungs. As red blood cells passes through the capillary beds of the lungs, gills (in fish), or other respiratory organs, oxygen is diffused into the erythrocytes and hemoglobin binds O2 and NO

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