Recitation Problems for Group Project- Overcoming Experimental Difficulties Name
ID: 1025018 • Letter: R
Question
Recitation Problems for Group Project- Overcoming Experimental Difficulties Name Section Recitation problems may be collected randomly for a grade. These questions are designed to help your group think critically toward solving issues that might have been faced on your first day of experimentation, in order to make the rest of your lab time as efficient as possible. Form two groups (3-4 people each) of researchers focusing on each reaction 1-3, but make sure these groups sit next to each other. Answer the following questions in these new groups: 1. If you were unsuccessful in completing your synthesis on the first attempt, or if you achieved impure product, what was the major obstacle to your success? What steps could you take during reaction preparation or reflux to improve this result? 2. Encountering problems during separation/purification is a very common issue in organic synthesis, but these steps are crucial to isolate your desired product. a. Use your textbook or other sources to get an idea of the relative polarity/solubility of all possibl compounds in your product mixture that need to be separated. Many times, compounds are listed with a relative polarity to water. b. What issues could arise during extraction if you had a significant amount of starting material present within your product mixture? c. Which of the following would be less likely to dissolve organic compounds, water or an aq. salt solution? Why?Explanation / Answer
1) We should need understand the reaction. We need to know what type of reaction exothermic, endothermic and moisture sensitive. Take equal moles of substrate, reagent and sufficient amount of solvent. For example intermolecular addition reactions progressed in high concentration and intramolecular addition reactions undergo to form product with good yield. 2) If product is polar compound (alcohols, acids, amines and polyhydroxy functional groups) carefully workup with the organic solvent and aqueous salt solution. otherwise workup with the organic solvent and water. Product and remaining starting material mixture come to the organic solvent.
Check the thin layer chromatography(TLC) differentiate the product and reactants in mixture and separated by column chromatography.
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