Use the following mechanism of Enolase to answer Question 21 - 24. Lysine 345 fu

Question

Use the following mechanism of Enolase to answer Question 21 - 24. Lysine 345 functions as: an electrophile. a specific base. a general base. a general acid. a nucleophile. Glutamate 211 functions as: a general acid. an electrophile. a specific acid. a specific base. a nucleophile. The magnesium ions function as: an oxidant. a nucleophile. an electrophile. a specific acid. a specific base. Which class of enzyme is enolase? Oxidoreductase Transferase Hydrolase Isomerase Lyase A transition-state analog: Has a higher K_s than the normal substrate. resembles the transition-state structure of the normal enzyme-substrate complex stabilizes the transition state for the normal enzyme-substrate complex. typically reacts more rapidly with an enzyme than the normal substrate. is less stable when binding to an enzyme than the normal substrate.

Explanation / Answer

21) In the reaction Lysine abstracting a H+ and the rate depends only on the Lysine and not on other base present in the system (Glutamate is amino acid, which has animo group which is also a base), so its a a specific base. So the answer is

B . A specific base

22) Glutamate is reacting with -OH so answer is

A. General acid

23) Mg+2 is positively charged and has lone pair of electrons so its an eletrophile. So the answer is

C. An electrophile

24) Answer is

E. Lyase

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