2) Normal blood clotting is dominant to Hemophilia. Hemophilia occurs more frequ

Question

2) Normal blood clotting is dominant to Hemophilia.

Hemophilia occurs more frequently in men than in women; however, it is possible for women to have hemophilia.

a) Identify the chromosome that carries this trait, and explain why that makes hemophilia more common in men.

b) Assign letters to this trait, and then provide the following:

i) GENOTYPE of a man with hemophilia. ii) GENOTYPE of a woman that would have hemophilia.

c) Set up a Punnett square that results in a daughter having hemophilia (there is more than one possible Punnett square for this answer)

d) Which parent is responsible for giving a son hemophilia? Explain your answer.

Explanation / Answer

Answer:

a) Hemophilia gene is located on the X-Chromosome of a sex chromosome. It is a X-linked Recessive trait. Males have only one X chromosome, whereas females have two X-chromosomes, so if male has one affected chromosome, it may lead to disease.

b)

XHXH = Normal Female

XHXh= Carrier Female

XhXh = affected Female

XhY = Affected Male

c)

1) XhXh (Affected Female) x XhY (Affected Male)

In above Punnet Square all Son and daughters are affected with Hemophilia

2) XHXh (Carrier Female) x XhY (Affected Male)

XhXh    and   XhY    are affected by Hemophilia

d) If both parents are with Hemphilia , son may get hemophili

( XhXh (Affected Female) x XhY (Affected Male))

XHXh (Carrier Female) x XhY (Affected Male)

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