You are analyzing the sequence of a structural protein from muscle tissues of in
ID: 1006873 • Letter: Y
Question
You are analyzing the sequence of a structural protein from muscle tissues of individuals with a debilitating muscle weakness disease. When comparing the sequence to that of the same protein in asymptomatic relatives of these individuals, you notice that many of the persons with the disease have two prolines within 6 amino acids of each other, in one stretch of residues, whereas their relatives without the disease have Ala/Ala or Ala/Val at these positions. You carry out a secondary structure prediction of the protein. Which of the following possibilities is reasonable as an explanation for why the prolines might give rise to a disease-related protein? Choose the best answer.
Substituting Ala or Val residues with prolines eliminates negative charges that would otherwise be presentExplanation / Answer
Statement explaning hy proline migh give rise to disease-related protein is,
The proline substitution disrupts several beta-strands that might otherwis be present.
Related Questions
drjack9650@gmail.com
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.