The following table contains amino acid transfer free energy data (octanol to wa

Question

The following table contains amino acid transfer free energy data (octanol to water in kcal/mol): The amino acid type is listed in the far left column. This is followed by three columns that list atomic surface area (ASA) values (Å2) for carbon, positively charged nitrogen and negatively charged oxygen atoms found in the various amino acids. The final column on the far right lists experimentally determined amino acid transfer free energies from octanol to water (kcal/mol), Your task is to use excel to develop a multiple linear regression model that relates the dependent variable (dG) to the three independent variables (C, N+ and O- surface area values) and then apply the regression equation to predict the transfer free energy for a small peptide. With the above in mind, answer the following questions (circle the correct answers).

2a. The regression equation is given by:
a. dG = 0.016ASAc - 0.034ASAN+-0.049ASAO-- 0.59
b. dG = 0.16ASAc - 0.049ASAN+- 0.034ASAO-+ 0.59
c. dG = 1.6ASAc + 0.049ASAN++ 0.034ASAO-+ 0.89
d. none of the above

2b. The overall regression equation is statistically significant:
a. True
b. False

2c. Using the regression equation, the predicted dG for a AAA tri-peptide is roughly:
a. 16.6 kcal/mol
b. 2.29 kcal/mol
c. -2.29 kcal/mol
d. -3.6 kcal/mol

Explanation / Answer

2 a) A regression equation is used in stats to find out what relationship, if any, exists between sets of data. Regression equations can help you figure out if your data can be fit to an equation.

option a ) is regression equation.

2 b) The overall regression equation is statistically significant: True.

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