Which of the following statements about regulation during fasting is False? Sele

Question

Which of the following statements about regulation during fasting is False? Select one: a. Glucagon is released from the pancreas b. More Glucose is produced by the liver by gluconeogenesis c. Glycogenolysis in the liver is inhibited. d. More ketone bodies are produced in the liver from increased [AcetylCoA] Which of the following statements is False? (Select all that apply) Select one or more: a. 5'AMP integrates the regulation of glycogenolysis as well as Glycogenesis. b. Protein Phosphatase-1 hydrolyzes the phosphate group from active Glycogen phosphorylase as well as active Glycogen Synthase. c. Glycogen synthase is made active by Phosphorylation d. Glycogen Phosphorylase (or Phosphorylase) is made active by Phosphorylation.

Explanation / Answer

Question first:

Option c is false :

During fasting glucose level is reduced in blood. Generally glucose is provided by food as an energy source. During fasting or long gap between diets amount of glucose in blood decreased. These reduced level of glucose is compensated by processes such as:

1. Glycogenolysis: Breakdown of stored glucose (glycogen). Lysis of stored glycogen and release of glucose molecules. Glycogen is present in liver and breakdown of glycogen to form glucose occurs in liver.

2. Gluconeogenesis: formation of glucose from non glucose components. Then produced glucose is used to generate energy.

Glucagon is hormone secreted by pancreas responsible to maintain blood glucose level. When glucose is low in blood, pancreas secretes glucagon which activates liver to form glucose.

Acetyl coA is a product of fatty acid breakdown reaction. When glucose amount in blood is low fatty acids undergo breakdown and form acetyl coA which further forms ketone bodies.

So glycogenolysis in liver is favoured at the time of fasting.

Question 2:

AMP means low level of ATP means High requirement of glucose as energy source. So AMP involved in regulation of both. (Option A is correct)

Option c is wrong :

glycogen synthase enzyme is activated by dephosphorylation and involves in glucose storage in liver by forming glycogen.

Glycogen Phosphorylase do break down of glycogen and form glucose and this enzyme is activated by phosphorylation. (That’s why D option is correct)

Phsphorylase: means removal of phosphate group.

Kinase : enzyme responsible to transfer phosphate group from one to onother molecule.

Option b is correct: protein phosphatase 1 binds with phosphorylase and show reaction together.

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