5.2.1. Preparation of 1-(4-nitrophenyl)-1H-pyrrole/indole (1a-1b) A well-stirred

Question

5.2.1. Preparation of 1-(4-nitrophenyl)-1H-pyrrole/indole (1a-1b) A well-stirred mixture of pyrrole/indole (0.128 mol) and K2CO3 (35.4 g, 0.257 mol) in DMF (150 mL) was heated at 100 °C for 30 min. Then, p-fluoronitrobenzene (21.6 g, 0.153 mol) was added and the mixture was stirred for another 5 h. Upon cooling to room temperature, the mixture was poured into water (300 mL) to stir for 30 min and filtered. The residue was washed with water, dried to give crude product and then treated with diethyl ether to afford 1a-1b. 30 min. Then, p-fuoronitrobenzene (21.6 g, 0.153 mol) was added

Explanation / Answer

Given moles of pyrolle = 0.128 mol

Molas mass of pyrolle = 67.09 g/mol

Mass of pyrolle to be used = (Number of moles)*(molar mass)

= 0.128 mol * 67.09 g/mol = 8.588 g

Density of pyrolle = 0.967 g/ml

Volume of pyrolle = mass of pyrolle/density = (8.588 g)/(0.967 g/ml) = 8.881 ml

Volume of pyrolle to be used = 8.881 ml

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