a. Based on the pedigree, characterize each of the following modes of inheritanc
ID: 100176 • Letter: A
Question
a. Based on the pedigree, characterize each of the following modes of inheritance as likely, unlikely, or impossible: autosomal dominant, autosomal recessive, Y linked, X-linked dominant, and X-linked recessive. Justify your reasoning.
Further scrutiny of members of this family reveals the following:
1) The disease’s degree of expression varies among individuals, with some mildly affected, others moderately affected and still others severely affected; and 2) Individual III-14 was previously married. Her ex-husband is phenotypically normal, with no history of the disease in his family going back ten generations.
He has custody of the couple’s two children, a girl and a boy, both of whom are affected with the disease. The partial pedigree is shown below (the “slash” represents separation or divorce)
b. Do these findings eliminate any of the remaining “likely or unlikely” modes of inheritance listed in part (a)? Are any of these modes of inheritance still possible? If so, which one(s) and why?
c. Is mitochondrial inheritance a likely, unlikely or an impossible mode of inheritance for this disease? Does it provide an explanation for the disease’s variable expressivity?
d. How can mitochondrial inheritance explain individual III-14?
12 13 14 IV 12 13 14Explanation / Answer
1) Answer:
the pedigree diagram given above is the pedigree of the autosomal recessive disease which leads to the disease known as rare neurodegenerative disease.
because in the autosomal recessive disease we can see that it will skip the generation and this skipping occurs in III-14
because as mentioned in the given question III-14 is previously married and she had a girl and a boy from her X-husband who is unaffected so as both the parents are unaffected their children are affected with this rare disorder.
This can only happen in the autosomal recessive disease which occurs which skipping the generation.
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